Correlation of glucose concentrations in maternal serum and amniotic fluid in high-risk pregnancies.

Abstract

OBJECTIVE:

We sought to determine whether a correlation exists between maternal serum glucose and amniotic fluid glucose in high-risk pregnancies.

STUDY DESIGN:

We conducted a prospective cross-sectional study of 60 patients, between 15 and 38 weeks' gestation, undergoing amniocentesis between March 2006 and April 2007. Participants underwent amniocentesis with evaluation of amniotic fluid glucose and maternal finger stick glucose. Data were collected on maternal demographics, gestational age, presence of diabetes or chorioamnionitis, use of betamethasone, and body mass index. Statistical analyses included Spearman rho correlations.

RESULTS:

A positive correlation was found between maternal serum glucose and amniotic fluid glucose (r = 0.401, P < .01), and amniotic fluid index and diabetes (r = 0.367, P < .05). An inverse correlation was found between amniotic fluid glucose and chorioamnionitis (r = -0.499, P < .01).

CONCLUSION:

Maternal hyperglycemia directly influences amniotic fluid glucose levels and may result in an elevated amniotic fluid glucose value.

• Authors: Sara G Rinala, Vicki L Dryfhout, Donna S Lambers
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 200 Issue 5 Pg. e43-4 (May 2009) ISSN: 1097-6868 [Electronic] United States
• PMID: 19110216 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose

Topics

• Adult
• Amniocentesis
• Amniotic Fluid (metabolism)
• Blood Glucose (metabolism)
• Chorioamnionitis (epidemiology, metabolism)
• Cross-Sectional Studies
• Female
• Humans
• Pregnancy
• Pregnancy Complications (epidemiology, metabolism)
• Prospective Studies
• Risk Factors
• Young Adult