Abstract | BACKGROUND: METHODS: From January 2005 to March 2007, we enrolled 5338 patients who received upper gastrointestinal endoscopy. Prevalence and length of endoscopically identified SSBE were evaluated within groups divided on the basis of 10-year age intervals. The factors possibly influencing SSBE length such as symptoms, antacid use, and endoscopic findings were also evaluated. Additionally, the length change in 236 patients with histologically confirmed Barrett's esophagus was evaluated over a 2-year follow-up. RESULTS: Of the 5338 enrolled patients, 1997 had SSBE. The prevalence of endoscopically identified SSBE was significantly higher and its length was significantly longer in elderly patients. Multiple regression analysis showed that age, presence of reflux esophagitis, reflux symptoms, and hiatal hernia were positively correlated with SSBE length. Analysis of the 2-year follow-up study of histologically confirmed SSBE revealed significant extension of Barrett's length in 28.0% of 236 patients. Presence of reflux symptoms and hiatal hernia were identified as positive predictors and proton pump inhibitor administration as a negative predictor of SSBE elongation. CONCLUSIONS: Positive predictors for the extension of SSBE were presence of hiatal hernia and reflux symptoms, but not age.
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Authors | Koichi Okita, Yuji Amano, Yoshiko Takahashi, Yuko Mishima, Nobuyuki Moriyama, Norihisa Ishimura, Shunji Ishihara, Yoshikazu Kinoshita |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 43
Issue 12
Pg. 928-34
( 2008)
ISSN: 0944-1174 [Print] Japan |
PMID | 19107336
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Barrett Esophagus
(epidemiology, pathology)
- Endoscopy, Gastrointestinal
- Female
- Follow-Up Studies
- Hernia, Hiatal
(complications)
- Humans
- Japan
(epidemiology)
- Male
- Middle Aged
- Prevalence
- Proton Pump Inhibitors
(therapeutic use)
- Regression Analysis
- Risk Factors
- Time Factors
- Young Adult
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