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[Advantages of corticosteroids in managing acute bacterial postoperative endophthalmitis].

Abstract
Most studies show a trend toward a beneficial or at least neutral effect of associating corticosteroids and antibiotics. However, caution must be taken, with various factors considered: the type, virulence, and size of the inoculum, and the treatment chosen. Early intravitreal administration of 400 microg of dexamethasone seems to be beneficial in treating postoperative Staphylococcus epidermidis-related endophthalmitis. However, a large-scale prospective, randomized, controlled study is mandatory to gain evidence supporting steroid therapy in postoperative endophthalmitis.
AuthorsM Saleh, F Jehl, G Prevost, C Speeg-Schatz, T Bourcier
JournalJournal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 31 Issue 8 Pg. 825-33 (Oct 2008) ISSN: 1773-0597 [Electronic] France
Vernacular TitleIntérêt des corticoïdes dans la prise en charge de l'endophtalmie postopératoire aiguë bactérienne.
PMID19107051 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Cytokines
Topics
  • Adrenal Cortex Hormones (administration & dosage, therapeutic use)
  • Animals
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Anti-Inflammatory Agents (administration & dosage, therapeutic use)
  • Combined Modality Therapy
  • Cytokines (physiology)
  • Drug Evaluation, Preclinical
  • Drug Therapy, Combination
  • Endophthalmitis (drug therapy, etiology, surgery)
  • Humans
  • Injections
  • Mice
  • Models, Biological
  • Postoperative Complications (drug therapy, etiology)
  • Prospective Studies
  • Randomized Controlled Trials as Topic (statistics & numerical data)
  • Retinal Detachment (etiology, prevention & control)
  • Staphylococcal Infections (drug therapy, etiology)
  • Vitrectomy (methods)
  • Vitreous Body

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