[A partial response to combined S-1 and CDDP chemotherapy enabling a curative resection in a patient with locally advanced duodenal cancer].
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| Abstract |
A 60-year-old male presented with a primary complaint of back pain. CT revealed a primary duodenal tumor with bulky lymph node metastases. Gastrofiberscopy revealed a primary duodenal tumor located the second portion. The patient was treated with combined chemotherapy using S-1 and CDDP to prior to performing a surgical curative resection. S-1 (80 mg/m2) was orally administered for 3 weeks (day 1-21), and CDDP (60 mg/m2) was simultaneously administered on day 8 every 5 weeks. The chemotherapy was repeated for 2 cycles. The patient experienced no adverse event. CT revealed a partial response after chemotherapy. The patient underwent a curative pancreaticoduodenectomy. The pathological efficacy was Grade 2. Adjuvant chemotherapy was provided using S-1 regimen because of its pathological efficacy and the absence of severe adverse events. Six months after the operation, the patient was doing well and showed no signs of recurrence of the cancer. This S-1/CDDP combination chemotherapy was therefore considered to be suitable as neo-adjuvant chemotherapy because it permitted the patient to subsequently undergo a curative resection, and thereby achieving a survival benefit for locally advanced duodenal cancer.
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| Authors | Tomohisa Egawa, Masaki Ohashi, Yasuhiro Ito, Shinobu Hayashi, Masakazu Doi, Atsushi Nagashima |
| Journal | Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 12 Pg. 2083-5 (Nov 2008) ISSN: 0385-0684 [Print] Japan |
| PMID | 19106531 (Publication Type: Case Reports, Journal Article) |
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