[Possibilities for optimization of radiotherapy of esophageal carcinoma through measurement of the oncoradiogenic enzyme peak of glucosephosphate isomerase].

Abstract

In 20 patients with oesophageal carcinoma blood samples were taken after the first irradiation and the activity of the glycolytic enzyme glucose-6-phosphate isomerase was measured. In all patients there occur GPI peaks at reproducible times. The height of the enzyme peak occurring 15.5 to 19.5 hours p.irr. expresses a significant dependence on tumour size and irradiation dose. The frequency of a late occurring enzyme peak depends on the appearance of regional lymph node metastases. Possible sources of the enzyme peaks are discussed from a radiobiological point of view and the meaning of such enzyme peaks for the optimization of radiation therapy is pointed out.

• Authors: D Tunak, M Below, K H Dallüge, P Henkel, T Nicolai, F Kuchenbecker
• Journal: Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR (Gastroenterol J) Vol. 51 Issue 1 Pg. 22-6 ( 1991) ISSN: 0863-1743 [Print] Germany
• Vernacular Title: Möglichkeiten der Optimierung der Strahlentherapie von Oesophaguskarzinomen durch die Messung des onkoradiogenen Enzympeaks der GPI.
• PMID: 1910491 (Publication Type: English Abstract, Journal Article)

Chemical References

• Glucose-6-Phosphate Isomerase

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (enzymology, radiotherapy)
• Esophageal Neoplasms (enzymology, radiotherapy)
• Female
• Glucose-6-Phosphate Isomerase (blood)
• Humans
• Lymphatic Metastasis
• Male
• Middle Aged
• Patient Care Planning
• Plasma Volume
• Radiotherapy Dosage
• Time Factors