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Susceptibility testing of Listeria monocytogenes. A reassessment of bactericidal activity as a predictor for clinical outcome.

Abstract
In vitro susceptibility testing of Listeria monocytogenes most often reveals both ampicillin and penicillin as inhibitory as opposed to bactericidal with activity comparable to chloramphenicol and tetracycline. Yet, the former two penicillins are more effective for Listeria meningitis than are the latter agents. Accordingly, we reassessed the bactericidal activity of agents used in listeriosis in order to determine in vitro methodology that would be more predictive of clinical outcome. We found that bactericidal activity for greater than 48 hr by either minimum inhibitory-minimum bactericidal concentration (MIC-MBC) testing or time-kill kinetic studies was the best predictor of clinical efficacy. This correlation may be due to Listeria being a slow-growing microorganism. In addition to ampicillin and penicillin, we found trimethoprim-sulfamethoxazole, vancomycin, and imipenem to exhibit bactericidal activity for 48 hr. For the first two agents, this is in agreement with the results of clinical experience.
AuthorsM D Appleman, C E Cherubin, P N Heseltine, C W Stratton
JournalDiagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) 1991 Jul-Aug Vol. 14 Issue 4 Pg. 311-7 ISSN: 0732-8893 [Print] United States
PMID1909614 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Penicillins
  • Chloramphenicol
  • Vancomycin
  • Imipenem
  • Ampicillin
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Tetracycline
Topics
  • Ampicillin (pharmacology)
  • Anti-Bacterial Agents (pharmacology)
  • Chloramphenicol (pharmacology)
  • Humans
  • Imipenem (pharmacology)
  • Kinetics
  • Listeria monocytogenes (drug effects)
  • Microbial Sensitivity Tests
  • Penicillins (pharmacology)
  • Tetracycline (pharmacology)
  • Trimethoprim, Sulfamethoxazole Drug Combination (pharmacology)
  • Vancomycin (pharmacology)

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