Vibrational spectroscopic study of fluticasone propionate.

Abstract

Fluticasone propionate is a synthetic glucocorticoid with potent anti-inflammatory activity that has been used effectively in the treatment of chronic asthma. The present work reports a vibrational spectroscopic study of fluticasone propionate and gives proposed molecular assignments on the basis of ab initio calculations using BLYP density functional theory with a 6-31G* basis set and vibrational frequencies predicted within the quasi-harmonic approximation. Several spectral features and band intensities are explained. This study generated a library of information that can be employed to aid the process monitoring of fluticasone propionate.

• Authors: H R H Ali, H G M Edwards, J Kendrick, I J Scowen
• Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (Spectrochim Acta A Mol Biomol Spectrosc) Vol. 72 Issue 2 Pg. 244-7 (Mar 2009) ISSN: 1386-1425 [Print] England
• PMID: 19095495 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Androstadienes
• Anti-Inflammatory Agents
• Fluticasone

Topics

• Androstadienes (chemistry)
• Anti-Inflammatory Agents (chemistry)
• Fluticasone
• Molecular Structure
• Spectrum Analysis, Raman
• Vibration