Abstract | BACKGROUND: METHODS: RESULTS: During 10 years of follow-up, 1076 (72%) patients with MI and 1336 (89%) patients with HF died. In multivariable adjusted models, every increment in baseline heart rate of 10 bpm was associated with an increase in mortality in both MI-patients (hazard ratio, 1.14; 95%-confidence interval (CI): 1.09-1.19; P<.0001) and HF-patients (hazard ratio, 1.10; CI: 1.06-1.15; P<.0001). The importance of resting heart rate on short-term prognosis was stronger in the MI patients compared to the HF patients (P<.0001 for interaction). There was no interaction between heart rate and beta-blockade, and inclusion of beta-blockade in the model did not change the results. CONCLUSIONS: Resting heart rate was independently associated with increased risk of overall mortality. The prognostic importance of resting heart rate is stronger in patients with MI compared to patients with HF, especially in the short term.
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Authors | Emil Loldrup Fosbøl, Marie Seibaek, Bente Brendorp, Daniel Vega Moller, Jens Jakob Thune, Gunnar H Gislason, Christian Torp-Pedersen, Lars Køber, Danish Investigations and Arrhythmia ON Dofetilide Study Group |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 140
Issue 3
Pg. 279-86
(Apr 30 2010)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 19095316
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved. |
Topics |
- Aged
- Aged, 80 and over
- Denmark
(epidemiology)
- Female
- Follow-Up Studies
- Heart Failure
(complications)
- Heart Rate
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Myocardial Infarction
(complications)
- Prognosis
- Proportional Hazards Models
- Survival Rate
- Ventricular Dysfunction, Left
(diagnosis, etiology, mortality)
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