[Vascular effects of ginseng compounds].

Abstract

In the review it has been systematized data on the vascular effects of ginsenosides in vivo. It has been shown that ginsenosides increase a tolerance of isolated arteries to oxidative stress, hypoxia-reoxigenation, homocysteine and other pathogenic factors. It has been performed an analysis published works on the effects of triterpene saponines on the NO synthesis in the isolated endothelial cells, a proliferation of these cells, an apoptosis of endotheliocytes, a secretion of vascular endothelial growth factor by endothelial cells. It was exhibited data on the potency of ginsenosides to inhibit a proliferation of vascular smooth muscle cells. It has been discussed a molecular mechanisms of triterpene saponines action, their interaction with steroid hormone receptors, proteinkinases, NO-synthase, guanilyl cyclase, K(Ca)-channels, Ca(2+)-channels.

• Authors: L N Maslov, Iu B Lishmanov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2008 Sep-Oct Vol. 71 Issue 5 Pg. 58-68 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 19093375 (Publication Type: Journal Article, Review)

Chemical References

• Calcium Channels
• Ginsenosides
• Potassium Channels
• Receptors, Steroid
• Homocysteine
• Nitric Oxide
• Nitric Oxide Synthase
• Guanylate Cyclase

Topics

• Animals
• Apoptosis (drug effects)
• Calcium Channels (metabolism)
• Cell Proliferation (drug effects)
• Endothelial Cells (metabolism)
• Ginsenosides (chemistry, pharmacology)
• Guanylate Cyclase (metabolism)
• Homocysteine (metabolism)
• Humans
• Hypoxia (drug therapy, metabolism)
• Muscle, Smooth, Vascular (metabolism)
• Myocytes, Smooth Muscle (metabolism)
• Nitric Oxide (metabolism)
• Nitric Oxide Synthase (metabolism)
• Oxidative Stress (drug effects)
• Panax (chemistry)
• Potassium Channels (metabolism)
• Receptors, Steroid (metabolism)