Review article: panitumumab--a fully human anti-EGFR monoclonal antibody for treatment of metastatic colorectal cancer.

Panitumumab is a fully human monoclonal IgG2 antibody targeting the epidermal growth factor receptor (EGFR).
To review the efficacy of panitumumab in the treatment of metastatic colorectal cancer (mCRC).
Available literature identified from PubMed and conference websites was reviewed.
In phase 2-3 studies, panitumumab monotherapy achieved objective response rates (ORRs) of 8-13% in relapsed/refractory EGFR-expressing mCRC. In a randomized phase 3 study (463 patients), panitumumab almost halved the risk of disease progression/death vs. a control group receiving only best supportive care (hazard ratio 0.54; 95% CI: 0.44-0.66; P < 0.0001). Objective response was achieved in 22/231 (10%) patients randomized to panitumumab--and also in 20/176 (11%) patients assigned to the control group who received panitumumab in a separate crossover protocol after disease progression. Response was confined to patients with tumours harbouring wild-type KRAS (ORR approximately equal to 20%). Panitumumab is also being evaluated in earlier lines of treatment. Panitumumab monotherapy is generally well tolerated; the most common toxicities are skin toxicity (approximately equal to 90%) and diarrhoea (<30%). Development of anti-panitumumab antibodies (0.3% by ELISA) and grade 3-4 infusion reactions (<1%) are rare.
Panitumumab is an effective monotherapy option for patients with relapsed/refractory EGFR-expressing mCRC harbouring wild-type KRAS.
AuthorsM Peeters, J Balfour, D Arnold
JournalAlimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 28 Issue 3 Pg. 269-81 (Aug 1 2008) ISSN: 0269-2813 [Print] England
PMID19086328 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Biomarkers, Tumor
  • Immunoglobulin G
  • KRAS protein, human
  • Proto-Oncogene Proteins
  • panitumumab
  • ras Proteins
  • Cetuximab
  • Adenocarcinoma (drug therapy, genetics, secondary)
  • Antibodies, Monoclonal (administration & dosage)
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Biomarkers, Tumor (genetics)
  • Cetuximab
  • Clinical Trials as Topic
  • Colorectal Neoplasms (drug therapy, genetics, secondary)
  • Disease-Free Survival
  • Female
  • Humans
  • Immunoglobulin G (genetics)
  • Male
  • Patient Selection
  • Proto-Oncogene Proteins (administration & dosage)
  • ras Proteins (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: