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Review article: panitumumab--a fully human anti-EGFR monoclonal antibody for treatment of metastatic colorectal cancer.

AbstractBACKGROUND:
Panitumumab is a fully human monoclonal IgG2 antibody targeting the epidermal growth factor receptor (EGFR).
AIM:
To review the efficacy of panitumumab in the treatment of metastatic colorectal cancer (mCRC).
METHODS:
Available literature identified from PubMed and conference websites was reviewed.
RESULTS:
In phase 2-3 studies, panitumumab monotherapy achieved objective response rates (ORRs) of 8-13% in relapsed/refractory EGFR-expressing mCRC. In a randomized phase 3 study (463 patients), panitumumab almost halved the risk of disease progression/death vs. a control group receiving only best supportive care (hazard ratio 0.54; 95% CI: 0.44-0.66; P < 0.0001). Objective response was achieved in 22/231 (10%) patients randomized to panitumumab--and also in 20/176 (11%) patients assigned to the control group who received panitumumab in a separate crossover protocol after disease progression. Response was confined to patients with tumours harbouring wild-type KRAS (ORR approximately equal to 20%). Panitumumab is also being evaluated in earlier lines of treatment. Panitumumab monotherapy is generally well tolerated; the most common toxicities are skin toxicity (approximately equal to 90%) and diarrhoea (<30%). Development of anti-panitumumab antibodies (0.3% by ELISA) and grade 3-4 infusion reactions (<1%) are rare.
CONCLUSION:
Panitumumab is an effective monotherapy option for patients with relapsed/refractory EGFR-expressing mCRC harbouring wild-type KRAS.
AuthorsM Peeters, J Balfour, D Arnold
JournalAlimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 28 Issue 3 Pg. 269-81 (Aug 1 2008) ISSN: 0269-2813 [Print] England
PMID19086328 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Biomarkers, Tumor
  • Immunoglobulin G
  • KRAS protein, human
  • Proto-Oncogene Proteins
  • panitumumab
  • ras Proteins
  • Cetuximab
Topics
  • Adenocarcinoma (drug therapy, genetics, secondary)
  • Antibodies, Monoclonal (administration & dosage)
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Biomarkers, Tumor (genetics)
  • Cetuximab
  • Clinical Trials as Topic
  • Colorectal Neoplasms (drug therapy, genetics, secondary)
  • Disease-Free Survival
  • Female
  • Humans
  • Immunoglobulin G (genetics)
  • Male
  • Patient Selection
  • Proto-Oncogene Proteins (administration & dosage)
  • ras Proteins (administration & dosage)

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