HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Alkaptonuria presenting with ochronotic spondyloarthropathy.

Abstract
Alkaptonuria is a rare autosomal recessive metabolic disease that leads to the deposition of homogentisic acid. Ochronotic arthropathy is the articular manifestation of alkaptonuria with the most common clinical feature being severe spondyloarthropathy. We present the case of a 58-year-old woman with back pain. Radiographs and magnetic resonance imaging (MRI) revealed characteristic features of ochronotic spondyloarthropathy. The literature regarding management of alkaptonuria is reviewed.
AuthorsR Al-Mahfoudh, S Clark, N Buxton
JournalBritish journal of neurosurgery (Br J Neurosurg) Vol. 22 Issue 6 Pg. 805-7 (Dec 2008) ISSN: 1360-046X [Electronic] England
PMID19085367 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Antioxidants
  • Homogentisate 1,2-Dioxygenase
  • Homogentisic Acid
  • Ascorbic Acid
Topics
  • Alkaptonuria (complications, metabolism)
  • Antioxidants (therapeutic use)
  • Ascorbic Acid (therapeutic use)
  • Female
  • Homogentisate 1,2-Dioxygenase (metabolism)
  • Homogentisic Acid (metabolism)
  • Humans
  • Low Back Pain (etiology, therapy)
  • Middle Aged
  • Ochronosis (etiology, metabolism)
  • Spondylarthropathies (etiology, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: