Abstract | OBJECTIVE: METHODS: RESULTS: Garlic extracts inhibited the oxidative modification of lipids, thus protecting cells from injury by the oxidized molecules. The best chemopreventive action of garlic was observed in mice in which garlic treatment was performed before and after the induction of skin carcinogenesis. Garlic ingestion delayed formation of skin papillomas in animals and simultaneously decreased the size and number of papillomas, which was also reflected in the skin histology of the mice treated. CONCLUSION: The protective effects against skin cancer elicited by garlic in mice are believed to be due at least in part to the induction cellular defense systems.
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Authors | Ila Das, Tapas Saha |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 25
Issue 4
Pg. 459-71
(Apr 2009)
ISSN: 0899-9007 [Print] United States |
PMID | 19084378
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Antioxidants
- Benz(a)Anthracenes
- Biomarkers
- Carcinogens
- Plant Extracts
- Tumor Suppressor Protein p53
- 7,12-dihydroxymethylbenz(a)anthracene
- 9,10-Dimethyl-1,2-benzanthracene
- Cyclooxygenase 2
- Caspase 3
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Topics |
- 9,10-Dimethyl-1,2-benzanthracene
(adverse effects)
- Animals
- Antineoplastic Agents, Phytogenic
(pharmacology, therapeutic use)
- Antioxidants
(metabolism)
- Benz(a)Anthracenes
- Biomarkers
(metabolism)
- Body Weight
(drug effects)
- Carcinogens
- Caspase 3
(metabolism)
- Cyclooxygenase 2
(metabolism)
- Female
- Garlic
- Humans
- Lipid Peroxidation
(drug effects)
- Mice
- Papilloma
(drug therapy)
- Plant Extracts
(pharmacology)
- Skin
(anatomy & histology, drug effects)
- Skin Neoplasms
(chemically induced, pathology, prevention & control)
- Tumor Suppressor Protein p53
(metabolism)
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