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Down-regulation of protein and mRNA expression of IL-8 and ICAM-1 in colon tissue of ulcerative colitis patients by partition-herb moxibustion.

Abstract
Our previous studies have demonstrated the efficacy of partition-herb moxibustion on ulcerative colitis (UC) rats. However, the mechanism of actions of partition-herb moxibustion is still unclear. Most Chinese acupuncturists believe that partition-herb improves the effect of moxibustion therapy. However, this argument lacks confirming experimental and clinical evidence. So, whether partition-herb does play a role in the mechanism of actions of partition-herb moxibustion was reported in this paper. A total of 123 patients were randomly divided into the partition-herb moxibustion group and the control group (partition-bran moxibustion group). Fourteen patients dropped out of the study. Finally, 109 patients finished the intervention. Sixty-one patients with UC received partition-herb moxibustion and 48 patients with UC received partition-bran moxibustion for 72 treatments, one treatment per day, every 12 treatments with an interval of 3 days. The expressions of interleukin-8 (IL-8) and intercellular adhesion molecule-1 (ICAM-1) in the colonic mucosa tissue in mild patients with UC were assayed by immunohistochemistry and RT-PCR. Histology of the colon also was observed at entry and after 72 treatments. Clinical therapeutic effect in partition-herb moxibustion was significantly better than those in partition-bran moxibustion (P < 0.05). Protein and mRNA expression of IL-8, ICAM-1 in the patients was inhibited by both partition-herb moxibustion and partition-bran moxibustion, of those the inhibition in the partition-herb moxibustion group was more obvious (P < 0.01). Partition-herb moxibustion was shown to significantly improve the histology of the colon, and partition-herb was shown to improve the therapeutic effect of moxibustion on treatment of UC patients.
AuthorsEn-Hua Zhou, Hui-Rong Liu, Huan-Gan Wu, Zheng Shi, Wei Zhang, Yi Zhu, Da-Ren Shi, Shuang Zhou
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 54 Issue 10 Pg. 2198-206 (Oct 2009) ISSN: 1573-2568 [Electronic] United States
PMID19083096 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Interleukin-8
  • Proteins
  • RNA, Messenger
  • Intercellular Adhesion Molecule-1
Topics
  • Adolescent
  • Adult
  • Aged
  • Colitis, Ulcerative (metabolism, pathology, therapy)
  • Colon (chemistry, pathology)
  • Down-Regulation
  • Female
  • Humans
  • Immunohistochemistry
  • Intercellular Adhesion Molecule-1 (analysis, genetics)
  • Interleukin-8 (analysis, genetics)
  • Intestinal Mucosa (chemistry)
  • Male
  • Middle Aged
  • Moxibustion (methods)
  • Proteins (analysis)
  • RNA, Messenger (analysis)
  • Sigmoidoscopy

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