[Efficacy of 5-nitroimidazole derivatives in treatment of bacterial vaginosis].

Abstract

OBJECTIVE:

To evaluate the efficacy and adverse effects of 5-nitroimidazole derivatives in treatment of bacterial vaginosis (BV).

METHODS:

278 BV patients were randomly divided into 8 groups to be treated with (1) oral metronidazole sustained release tablet 750 mg/day for 7 days, (2) oral metronidazole sustained release tablet 750 mg/day for 7 days and vaginal tinidazole 250 mg for 7 days, (3) oral tinidazole 1 g/day for 3 days (2 g for the first dose), (4) oral tinidazole 1 g/day for 3 days (2 g for the first dose), (5) oral ornidazole 2 x 500 mg/day for 3 days and vaginal tinidazole 250 mg for 7 days, (6) oral ornidazole 2 x 500 mg/day for 3 days, (7) oral secnidazole 2 g in a single dose and vaginal tinidazole 250 mg for 7 days, and (8) oral secnidazole 2 g in a single dose.

RESULTS:

The clinical cure rates of the oral administration groups were 56.76% - 62.50%, all significantly lower than those of the oral/vaginal combination groups (80.00% - 86.11%, all P < 0.05). There was nit significantly difference in efficacy level among the only oral treatment groups and the oral/vaginal combination groups (all P > 0.05).

CONCLUSION:

Combination of oral and vaginal administration of 5-nitroimidazole derivatives is more effective in treatment of BV than oral administration only.

• Authors: Feng-Mei Wang, Xiao-Dan Qian, Hong Xu, He-Yong Yu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 88 Issue 31 Pg. 2201-3 (Aug 12 2008) ISSN: 0376-2491 [Print] China
• PMID: 19080672 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Delayed-Action Preparations
• Nitroimidazoles
• Tablets
• Tinidazole
• Metronidazole
• Ornidazole
• secnidazole

Topics

• Administration, Intravaginal
• Administration, Oral
• Adult
• Delayed-Action Preparations
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Humans
• Metronidazole (administration & dosage, analogs & derivatives, therapeutic use)
• Nitroimidazoles (administration & dosage, therapeutic use)
• Ornidazole (administration & dosage, therapeutic use)
• Prospective Studies
• Tablets
• Tinidazole (administration & dosage, therapeutic use)
• Treatment Outcome
• Vaginosis, Bacterial (drug therapy)
• Young Adult