HIV/AIDS: the management of treatment-experienced HIV-infected patients: new drugs and drug combinations.

The recent availability of new antiretroviral agents for the treatment of human immunodeficiency virus (HIV) infection has increased treatment options and has improved the durability, tolerability, and long-term efficacy of antiretroviral therapy, even among patients with extensive treatment experience and high levels of drug resistance. This expansion of therapeutic options has led to a revision of current treatment guidelines, which now state that the goal of antiretroviral therapy in all patients is suppression of the plasma HIV RNA level to <50 copies/mL. Successful management of infection for treatment-experienced patients with the new agents requires an understanding of their pharmacology and resistance patterns and the appropriate use of laboratory testing to optimize regimen selection. This review discusses the use of recently approved antiretroviral agents in the management of HIV infection in treatment-experienced patients.
AuthorsLucy E Wilson, Joel E Gallant
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 48 Issue 2 Pg. 214-21 (Jan 15 2009) ISSN: 1537-6591 [Electronic] United States
PMID19072245 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Anti-HIV Agents
  • Anti-HIV Agents (therapeutic use)
  • Antiretroviral Therapy, Highly Active (methods)
  • HIV Infections (drug therapy)
  • Humans
  • Practice Guidelines as Topic
  • Viral Load

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