[Recommended dosage adaptation based on renal function is not always sufficient to avoid betalactam antibiotics side effects].

Abstract

The potential neurotoxicity of betalactam antibiotics are well-known and is frequently associated with drug accumulation in patients with renal failure since these antibiotics are eliminated mostly by kidneys. The regional center of pharmacovigilance of Amiens has collected since 10 years, 20 notifications of neurotoxicity induced by betalactam antibiotics. The series included eight women and 12 men. Mean age was 65 years (26-84). The drug accumulation hypothesis was strengthened in nine cases by assays of plasma levels residual concentrations. In 17 cases, betalactam antibiotics dosage was adapted to creatinin clearance in accordance to the Summary of the Product Characteristics' (SPC) recommendations. For several drugs, no adaptation to renal function was proposed by SPC. Dosage adaptation based only on renal function as it's recommended is not always efficient to avoid neurological side effects.

• Authors: Anne-Sophie Lemaire-Hurtel, Valérie Gras-Champel, Lionel Hary, Kamel Masmoudi, Ziad Massy, Michel Andréjak
• Journal: Nephrologie & therapeutique (Nephrol Ther) Vol. 5 Issue 2 Pg. 144-8 (Apr 2009) ISSN: 1769-7255 [Print] France
• Vernacular Title: Les recommandations d'adaptation posologique à la fonction rénale ne sont pas toujours suffisantes pour éviter la neurotoxicité des bêtalactamines.
• PMID: 19071080 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• GABA Antagonists
• beta-Lactams
• Creatinine

Topics

• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (administration & dosage, adverse effects, pharmacokinetics)
• Creatinine (blood)
• Dose-Response Relationship, Drug
• Epilepsy (chemically induced, epidemiology)
• Female
• France (epidemiology)
• GABA Antagonists (adverse effects)
• Humans
• Kidney Diseases (complications, metabolism, physiopathology)
• Male
• Metabolic Clearance Rate
• Middle Aged
• Practice Guidelines as Topic
• Retrospective Studies
• beta-Lactams (administration & dosage, adverse effects, pharmacokinetics)