Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B.

Abstract

Imaging of cerebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar beta-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.

• Authors: Steven M Greenberg, Thomas Grabowski, M Edip Gurol, Maureen E Skehan, R N Kaveer Nandigam, John A Becker, Monica Garcia-Alloza, Claudia Prada, Matthew P Frosch, Jonathan Rosand, Anand Viswanathan, Eric E Smith, Keith A Johnson
• Journal: Annals of neurology (Ann Neurol) Vol. 64 Issue 5 Pg. 587-91 (Nov 2008) ISSN: 1531-8249 [Electronic] United States
• PMID: 19067370 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
• Amyloid beta-Peptides
• Aniline Compounds
• Thiazoles

Topics

• Adult
• Amyloid beta-Peptides (analysis)
• Aniline Compounds
• Brain (diagnostic imaging, metabolism, physiopathology)
• Brain Mapping (methods)
• Cerebral Amyloid Angiopathy (diagnostic imaging, metabolism, physiopathology)
• Cerebral Arteries (metabolism, pathology, physiopathology)
• Humans
• Male
• Occipital Lobe (diagnostic imaging, metabolism, physiopathology)
• Plaque, Amyloid (diagnostic imaging, metabolism, pathology)
• Positron-Emission Tomography (methods)
• Predictive Value of Tests
• Thiazoles