HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Influence of PEG-conjugated hemoglobin on tumor oxygenation and response to chemotherapy.

Abstract
Hypoxic tumors are significantly more malignant, metastatic, radio- and chemoresistant. The use of artificial oxygen carriers represents a new approach to the problem of hypoxia. In the present study, female athymic BALB/c nude mice bearing the cervical carcinoma were untreated or treated with cisplatin to determine whether administration of artificial oxygen carrier (PEG-conjugated Hemoglobin, PEG-Hb) could improve the tumor oxygenation and enhance the anti-tumor efficacy of cisplatin. Pimonidazole staining was employed to detect tumor tissue oxygenation status. We found that the application of a higher dose (0.6 g/kg) PEG-Hb could significantly ameliorate the hypoxic condition in cervical carcinoma xenograft models. Co-administration of PEG-Hb (0.6 g/kg) with cisplatin produced significant tumor growth inhibition and pro-apoptotic and anti-proliferative effects as compared to cisplatin alone. These suggest the evaluated PEG-Hb in this experiment has positive effects on cisplatin or cisplatin-based chemotherapy, and further work to optimize its application is warranted.
AuthorsMinghua Yu, Jianqun Han, Min Dai, Peilin Cui, Hongwei Li, Qian Liu, Ruijuan Xiu
JournalArtificial cells, blood substitutes, and immobilization biotechnology (Artif Cells Blood Substit Immobil Biotechnol) Vol. 36 Issue 6 Pg. 551-61 ( 2008) ISSN: 1532-4184 [Electronic] England
PMID19065307 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Substitutes
  • Hemoglobins
  • Nitroimidazoles
  • PEG-hemoglobin
  • Polyethylene Glycols
  • pimonidazole
  • Cisplatin
Topics
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Blood Substitutes (administration & dosage, pharmacology)
  • Cisplatin (administration & dosage, pharmacology)
  • Drug Synergism
  • Female
  • Hemoglobins (administration & dosage, pharmacology)
  • Hypoxia (drug therapy)
  • Mice
  • Mice, Inbred BALB C
  • Nitroimidazoles
  • Oxygen Consumption (drug effects)
  • Polyethylene Glycols (administration & dosage, pharmacology)
  • Treatment Outcome
  • Uterine Cervical Neoplasms (drug therapy, metabolism)
  • Xenograft Model Antitumor Assays

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: