Abstract |
Hypoxic tumors are significantly more malignant, metastatic, radio- and chemoresistant. The use of artificial oxygen carriers represents a new approach to the problem of hypoxia. In the present study, female athymic BALB/c nude mice bearing the cervical carcinoma were untreated or treated with cisplatin to determine whether administration of artificial oxygen carrier (PEG-conjugated Hemoglobin, PEG-Hb) could improve the tumor oxygenation and enhance the anti- tumor efficacy of cisplatin. Pimonidazole staining was employed to detect tumor tissue oxygenation status. We found that the application of a higher dose (0.6 g/kg) PEG-Hb could significantly ameliorate the hypoxic condition in cervical carcinoma xenograft models. Co-administration of PEG-Hb (0.6 g/kg) with cisplatin produced significant tumor growth inhibition and pro-apoptotic and anti-proliferative effects as compared to cisplatin alone. These suggest the evaluated PEG-Hb in this experiment has positive effects on cisplatin or cisplatin-based chemotherapy, and further work to optimize its application is warranted.
|
Authors | Minghua Yu, Jianqun Han, Min Dai, Peilin Cui, Hongwei Li, Qian Liu, Ruijuan Xiu |
Journal | Artificial cells, blood substitutes, and immobilization biotechnology
(Artif Cells Blood Substit Immobil Biotechnol)
Vol. 36
Issue 6
Pg. 551-61
( 2008)
ISSN: 1532-4184 [Electronic] England |
PMID | 19065307
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Blood Substitutes
- Hemoglobins
- Nitroimidazoles
- PEG-hemoglobin
- Polyethylene Glycols
- pimonidazole
- Cisplatin
|
Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Blood Substitutes
(administration & dosage, pharmacology)
- Cisplatin
(administration & dosage, pharmacology)
- Drug Synergism
- Female
- Hemoglobins
(administration & dosage, pharmacology)
- Hypoxia
(drug therapy)
- Mice
- Mice, Inbred BALB C
- Nitroimidazoles
- Oxygen Consumption
(drug effects)
- Polyethylene Glycols
(administration & dosage, pharmacology)
- Treatment Outcome
- Uterine Cervical Neoplasms
(drug therapy, metabolism)
- Xenograft Model Antitumor Assays
|