Abstract | BACKGROUND: OBJECTIVE: DESIGN: The Women's Antioxidant and Folic Acid Cardiovascular Study is a randomized placebo-controlled trial designed to test the effect of a combination of B vitamins (2.5 mg folic acid/d, 50 mg vitamin B-6/d, and 1 mg vitamin B-12/d) on secondary prevention of CVD. Female health professionals aged >or=40 y (n = 5442) with CVD or >or=3 coronary risk factors in 1998 (after folic acid fortification began in the United States) were randomly assigned to treatment. Shortly after randomization (mean: 1.2 y), a substudy of cognitive function was initiated among 2009 participants aged >or=65 y. Telephone cognitive function testing was administered up to 4 times over 5.4 y with 5 tests of general cognition, verbal memory, and category fluency. Repeated-measures analyses were conducted, and the primary outcome was a global composite score averaging all test results. RESULTS: Mean cognitive change from baseline did not differ between the B vitamin and placebo groups (difference in change in global score: 0.03; 95% CI: -0.03, 0.08; P = 0.30). However, supplementation appeared to preserve cognition among women with a low baseline dietary intake of B vitamins. CONCLUSIONS: Combined B vitamin supplementation did not delay cognitive decline among women with CVD or CVD risk factors. The possible cognitive benefits of supplementation among women with a low dietary intake of B vitamins warrant further study.
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Authors | Jae Hee Kang, Nancy Cook, JoAnn Manson, Julie E Buring, Christine M Albert, Francine Grodstein |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 88
Issue 6
Pg. 1602-10
(Dec 2008)
ISSN: 1938-3207 [Electronic] United States |
PMID | 19064521
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Homocysteine
- Vitamin B Complex
- Vitamin B 6
- Folic Acid
- Vitamin B 12
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Topics |
- Aged
- Aged, 80 and over
- Cardiovascular Diseases
(blood, epidemiology, prevention & control)
- Chi-Square Distribution
- Cognition
(drug effects)
- Cognition Disorders
(blood, epidemiology, prevention & control)
- Dietary Supplements
- Double-Blind Method
- Female
- Folic Acid
(administration & dosage)
- Follow-Up Studies
- Homocysteine
(blood)
- Humans
- Hyperhomocysteinemia
(complications)
- Psychometrics
- Risk Factors
- Statistics, Nonparametric
- Vitamin B 12
(administration & dosage)
- Vitamin B 6
(administration & dosage)
- Vitamin B Complex
(administration & dosage)
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