Abstract |
Normal T cells can mediate antileukemic reactivity after allogeneic stem cell transplantation and T cell targeting immunotherapy is now considered for patients receiving conventional chemotherapy. This antileukemic reactivity is most effective in patients with a low leukemia cell burden, and this burden is expected to be lowest early after transplantation/ chemotherapy when patients are cytopenic. Local T cell recruitment will then be essential for the efficiency of the antileukemic response. In this context, the authors compared the chemokine receptor expression for T cells derived from healthy individuals and acute myelogenous leukemia patients with therapy-induced cytopenia after conventional chemotherapy or allogeneic stem cell transplantation. Circulating CD3(+) T cells showed the same chemokine receptor expression for all three groups: CCR1(low), CCR2(low), CCR3(low), CCR4(intermediate), CCR5(intermediate), CCR7(low/intermediate), CXCR2(low), CXCR3(intermediate), and CXCR4(high). Thus, only minor differences between the groups were observed when comparing individual receptors, and we therefore conclude that the chemokine receptor profiles of circulating CD3(+) T cells show no qualitative and only minor quantitative differences for these three groups.
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Authors | Astrid Marta Olsnes, Elisabeth Ersvaer, Anita Ryningen, Oystein Bruserud |
Journal | Hematology (Amsterdam, Netherlands)
(Hematology)
Vol. 13
Issue 6
Pg. 329-32
(Dec 2008)
ISSN: 1607-8454 [Electronic] England |
PMID | 19055860
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CD3 Complex
- Receptors, Chemokine
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Topics |
- Adult
- Aged
- CD3 Complex
- Case-Control Studies
- Hematopoietic Stem Cell Transplantation
- Humans
- Leukemia, Myeloid, Acute
(complications, immunology, therapy)
- Middle Aged
- Pancytopenia
(chemically induced)
- Receptors, Chemokine
(analysis)
- T-Lymphocytes
(chemistry, immunology)
- Transplantation, Homologous
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