Donovanosis with auto-amputation of penis in a HIV-2 infected person.

Abstract

Donovanosis is a slowly progressive, granulomatous ulcerative disease , caused by Klebsiella (Calymmatobacterium) granulomatis. The disease is known to persist for years together, leading to complications. A male patient aged 30 years with underlying HIV-2 infection presented to the department of STD with painful ulceration over the genital region of 5 months duration, with absence of penis. Tissue smear from the ulcer and histopathological examination revealed large histiocytes with intracellular Donovan bodies (Pund cell). A final diagnosis of donovanosis with auto-amputation of penis with HIV-2 infection was made. The old conventional medicines, viz. streptomycin, doxycycline and amoxycillin, were effective. Though HIV-2 infections are milder than HIV-1 infections in all aspects, donovanosis in this HIV-2 infected case presented with complications. However, since the CD4 count was 748 cells/cmm, the severity is attributed to the long standing nature and negligence by the patient, and not to possible immunodeficiency.

• Authors: T S Chandra Gupta, Thrimurthulu Rayudu, Srinivasa V Murthy
• Journal: Indian journal of dermatology, venereology and leprology (Indian J Dermatol Venereol Leprol) 2008 Sep-Oct Vol. 74 Issue 5 Pg. 490-2 ISSN: 0973-3922 [Electronic] United States
• PMID: 19052412 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Amputation, Traumatic (complications, diagnosis)
• Granuloma Inguinale (complications, diagnosis)
• HIV Infections (complications, diagnosis)
• HIV-2
• Humans
• Male
• Penis (injuries, virology)