Abstract | CONCLUSION: OBJECTIVE: Exposure to styrene causes hearing loss and hair cell death in the middle frequency region in the cochlea. The current study was designed to examine the cell death pathways and the protective effect of L-NAC against styrene-induced cochlear injuries. MATERIALS AND METHODS: RESULTS: The styrene exposure caused a threshold shift of 15±4.3 dB. Both apoptosis and necrosis were involved in the pathogenesis of the cochlear lesion, but apoptosis appeared to be the major cell death pathway leading to the styrene ototoxicity. Treatment with L-NAC reduced the number of missing and dying outer hair cells (OHCs) and reduced the styrene-induced hearing loss.
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Authors | Wei Ping Yang, Bo Hua Hu, Guang Di Chen, Eric C Bielefeld, Donald Henderson |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 129
Issue 10
Pg. 1036-43
(Oct 2009)
ISSN: 1651-2251 [Electronic] England |
PMID | 19051069
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Free Radical Scavengers
- Styrene
- Glutathione
- Acetylcysteine
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Topics |
- Acetylcysteine
(pharmacology, therapeutic use)
- Animals
- Free Radical Scavengers
(pharmacology, therapeutic use)
- Glutathione
(metabolism)
- Hair Cells, Auditory, Outer
(drug effects)
- Hearing Loss
(chemically induced, metabolism, prevention & control)
- Rats
- Rats, Long-Evans
- Styrene
(toxicity)
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