Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy.

Abstract

OBJECTIVE:

To analyze the value of the hCG ratio of peritoneal serum versus venous serum (R(P/V)) for early diagnosis and prognostic evaluation of ectopic pregnancy (EP).

DESIGN:

Retrospective clinical study.

SETTING:

University hospital.

PATIENT(S):

One hundred three women with hemoperitoneum and positive urine hCG tests underwent laparoscopy or laparotomy.

INTERVENTION(S):

Venous serum and peritoneal serum samples were obtained; ultrasound was performed in all the patients; dilatation and curettage was used in 28 patients.

MAIN OUTCOME MEASURE(S):

Quantitative hCG and R(P/V).

RESULT(S):

The R(P/V) in EP (5.55 +/- 4.32) is apparently greater than that in hemoperitoneum with intrauterine pregnancy (hIUP; 0.61 +/- 0.18). The median R(P/V) is 4.07 in the EP group versus 0.60 in the hIUP group, with a suggested threshold value of 1.0 for their differential diagnosis. Moreover, the R(P/V) of EP shows the dominant difference between the patients with active bleeding (8.03 +/- 3.29, n = 24) and the patients without active bleeding (4.59 +/- 3.88, n = 16) when the hCG level of venous serum is more than 1500 U/L.

CONCLUSION(S):

R(P/V) could instantly diagnose ectopic pregnancy and differentiate it from hIUP.

• Authors: YuDong Wang, Hong Zhao, YinCheng Teng, LiHua Lu, JianQian Tong
• Journal: Fertility and sterility (Fertil Steril) Vol. 93 Issue 3 Pg. 702-5 (Feb 2010) ISSN: 1556-5653 [Electronic] United States
• PMID: 19046581 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Chemical References

• Chorionic Gonadotropin

Topics

• Chorionic Gonadotropin (blood)
• Diagnosis, Differential
• Early Diagnosis
• Female
• Hemoperitoneum (diagnosis, metabolism)
• Humans
• Pregnancy
• Pregnancy, Ectopic (blood, diagnosis)
• Prognosis
• ROC Curve
• Retrospective Studies
• Sensitivity and Specificity