Abstract | AIMS: METHODS AND RESULTS: Eighteen PH patients (age 57, range 35-79 years, 33% male) received bosentan. Six minute walk distance (6-MWD) and echocardiography were performed at baseline and after 1 year follow-up. After 1 year of treatment, 6-MWD increased (mean 60 +/- 41 m) in 67% of patients (responders). Baseline RV contraction duration was longer in responders, compared with non-responders (612 +/- 66 vs. 514 +/- 23 ms; P < 0.01). A baseline RV contraction duration >550 ms was associated with improved 6-MWD (sensitivity 83%, specificity 83%; P < 0.01). CONCLUSION: An improvement of 6-MWD during bosentan treatment was associated with a decrease in RV contraction duration and could be predicted by a baseline RV contraction duration >550 ms.
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Authors | Mariëlle G J Duffels, Maxim Hardziyenka, Sulaiman Surie, Rianne H A C M de Bruin-Bon, Elke S Hoendermis, Arie P J van Dijk, Berto J Bouma, Hanno L Tan, Rolf M F Berger, Paul Bresser, Barbara J M Mulder |
Journal | European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
(Eur J Echocardiogr)
Vol. 10
Issue 3
Pg. 433-8
(May 2009)
ISSN: 1532-2114 [Electronic] England |
PMID | 19042941
(Publication Type: Journal Article)
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Chemical References |
- Antihypertensive Agents
- Sulfonamides
- Bosentan
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Topics |
- Adult
- Aged
- Antihypertensive Agents
(therapeutic use)
- Bosentan
- Female
- Heart Ventricles
(diagnostic imaging)
- Hemodynamics
(drug effects)
- Humans
- Hypertension, Pulmonary
(diagnostic imaging, drug therapy)
- Male
- Middle Aged
- Myocardial Contraction
- Retrospective Studies
- Sulfonamides
(therapeutic use)
- Treatment Outcome
- Ultrasonography
- Ventricular Function, Right
(drug effects)
- Walking
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