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Thyroid dysfunction after combined therapy for laryngeal cancer: a prospective study.

AbstractOBJECTIVE:
The purpose of this study was to assess the incidence of the thyroid dysfunction in a group of patients treated with laryngectomy and radiotherapy for larynx cancer and to analyze the risk factors related to the development of hypothyroidism.
STUDY DESIGN:
This was a prospective study conducted in a tertiary center hospital.
SUBJECTS AND METHODS:
Thyroid function tests have been applied to 75 patients treated with surgery and radiotherapy preoperatively, before radiotherapy, and postoperatively. Risk factors have been analyzed by carrying out a multivariate analysis.
RESULTS:
All the patients were men with the mean age of 59.4 and an average follow-up of 28.6 months. The incidence of hypothyroidism was 49.3 percent. The average time to detection of hypothyroidism was 6 months after the completion of treatment. Radiotherapy dose, type of laryngectomy, extent of neck dissection, implementation of thyroid lobectomy, and presence of thyroiditis in specimens were risk factors for thyroid dysfunction.
CONCLUSIONS:
It is important to check the thyroid function periodically in these patients especially with risk factor to obtain early diagnosis and appropriate treatment.
AuthorsSeyhan Alkan, Serdar Baylancicek, Memet Ciftçic, Esra Sozen, Burhan Dadaş
JournalOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) Vol. 139 Issue 6 Pg. 787-91 (Dec 2008) ISSN: 0194-5998 [Print] England
PMID19041504 (Publication Type: Journal Article)
Topics
  • Chi-Square Distribution
  • Combined Modality Therapy
  • Humans
  • Incidence
  • Laryngeal Neoplasms (complications, pathology, radiotherapy, surgery)
  • Laryngectomy (adverse effects, methods)
  • Logistic Models
  • Male
  • Middle Aged
  • Neck Dissection (adverse effects, methods)
  • Neoplasm Staging
  • Prospective Studies
  • Radiotherapy Dosage
  • Risk Factors
  • Thyroid Diseases (epidemiology, etiology)
  • Thyroid Function Tests

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