Abstract |
The findings of the studies on poly(ADP-ribose) polymerase-1 (PARP-1) have suggested that the enzyme inactivation provides significant protection against systemic or tissue inflammation in animal models. It has also shown that the single-nucleotide polymorphism (Val762Ala) of the PARP-1 causes about 40% decrease of enzyme activity. The aim of this study was to analyze the association of the PARP-1 Val762Ala polymorphism in Turkish patients with rheumatoid arthritis. A total of 128 RA patients and 165 normal controls from the same geographic region were studied and polymerase chain reaction (PCR)-based restriction analysis was used to identify Val762Ala polymorphism of the PARP-1. Association analyses were performed using chi (2) tests. Our results indicated that the distribution of the PARP-1 genotypes and alleles did not differ significantly among subjects with or without RA (P > 0.05). The results of the study indicate that, for our Turkish sample, the V762A polymorphism of the PARP-1 may not be involved in susceptibility to RA, implying that the polymorphism may not function as a candidate gene marker for screening RA patients.
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Authors | Ilhan Onaran, Gülçin Tezcan, Levent Ozgönenel, Esra Cetin, Alper Tunga Ozdemir, Gönül Kanigür-Sultuybek |
Journal | Rheumatology international
(Rheumatol Int)
Vol. 29
Issue 7
Pg. 797-800
(May 2009)
ISSN: 1437-160X [Electronic] Germany |
PMID | 19030862
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Genetic Markers
- PARP1 protein, human
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerases
- Valine
- Alanine
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Topics |
- Adult
- Aged
- Alanine
(genetics)
- Amino Acid Substitution
(genetics)
- Arthritis, Rheumatoid
(enzymology, ethnology, genetics)
- DNA Mutational Analysis
- Female
- Gene Frequency
(genetics)
- Genetic Markers
(genetics)
- Genetic Predisposition to Disease
(genetics)
- Genetic Testing
- Genotype
- Humans
- Male
- Middle Aged
- Poly (ADP-Ribose) Polymerase-1
- Poly(ADP-ribose) Polymerases
(chemistry, genetics)
- Polymorphism, Genetic
(genetics)
- Turkey
(ethnology)
- Valine
(genetics)
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