Abstract | PURPOSE: MATERIALS AND METHODS: In the present study, an animal model was developed to investigate the effects of combined modality therapy on hearing. Albino guinea pigs were given equivalent protocol dosages of cis-platinum (3 parenteral courses), fractionated radiation (25 fractions over 5 weeks), or both. Click and tone burst auditory brainstem response (ABR) measurements were performed before and 6 weeks after the completion of treatment. RESULTS: Animals receiving radiation or cis-platinum and radiation experienced permanent significant ABR shifts at all frequencies, with 33% of the animals experiencing complete unilateral sensorineural hearing loss at 2 or more frequencies in the ear receiving the full radiation dose (7075 cGy over 25 fractions) (P < .05, paired t test analysis). The animals receiving 3 doses of cis-platinum had no significant ABR threshold shifts at 6 weeks. These data suggest that cis-platinum and radiation cause greater ototoxicity than cis-platinum alone. These findings correlate closely with sensorineural hearing loss in combined modality patients at our institution and in recent studies. CONCLUSIONS:
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Authors | Matthew W Miller, Gunther Riedel, Dick Hoistad, Carolyn Sutherland, Steven K Juhn, George L Adams, Robert Griffin, Frank G Ondrey |
Journal | American journal of otolaryngology
(Am J Otolaryngol)
2009 Jan-Feb
Vol. 30
Issue 1
Pg. 1-7
ISSN: 1532-818X [Electronic] United States |
PMID | 19027506
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Auditory Threshold
- Cisplatin
(toxicity)
- Combined Modality Therapy
- Disease Models, Animal
- Dose Fractionation, Radiation
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Evoked Potentials, Auditory, Brain Stem
- Guinea Pigs
- Hearing Loss, Sensorineural
(diagnosis, etiology)
- Probability
- Radiation Dosage
- Random Allocation
- Risk Assessment
- Sensitivity and Specificity
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