Abstract | CONTEXT: EVIDENCE ACQUISITION: EVIDENCE SYNTHESIS: Treatment against malignant pheochromocytoma with surgery, chemotherapy, or participation in clinical trials was not feasible because of the patient's poor performance status, the presence of multiple tumors, and the extension of the pheochromocytoma into the bones. Patient was treated with sunitinib, a potent tyrosine kinase inhibitor of vascular endothelial growth factor, platelet-derived growth factor, RET, c-KIT, and FLT-3 receptors. Six months of treatment with sunitinib was associated with normalization of the patient's performance status and blood pressure, absence of symptoms of catecholamine excess, weight gain, disappearance of pain, shrinkage of each of the tumors (50% in the largest renal tumor, 38% in the largest islet cell tumor, 21% in the pelvic malignant pheochromocytoma), and reduction of plasma normetanephrines and chromogranin A. CONCLUSION:
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Authors | Camilo Jimenez, Maria E Cabanillas, Libero Santarpia, Eric Jonasch, Karen L Kyle, Elizabeth A Lano, Surena F Matin, Rodolfo F Nunez, Nancy D Perrier, Alexandria Phan, Thereasa A Rich, Beejal Shah, Michelle D Williams, Steven G Waguespack |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 94
Issue 2
Pg. 386-91
(Feb 2009)
ISSN: 0021-972X [Print] United States |
PMID | 19017755
(Publication Type: Case Reports, Evaluation Study, Journal Article)
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Chemical References |
- Angiogenesis Inducing Agents
- Angiogenesis Inhibitors
- Indoles
- Protein Kinase Inhibitors
- Pyrroles
- Von Hippel-Lindau Tumor Suppressor Protein
- VHL protein, human
- Sunitinib
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Topics |
- Adrenal Gland Neoplasms
(blood supply, complications, drug therapy, genetics)
- Adult
- Angiogenesis Inducing Agents
(antagonists & inhibitors)
- Angiogenesis Inhibitors
(therapeutic use)
- Drug Delivery Systems
(methods)
- Female
- Humans
- Indoles
(therapeutic use)
- Neoplasms, Multiple Primary
(blood supply, drug therapy, genetics)
- Pheochromocytoma
(blood supply, complications, drug therapy, genetics)
- Protein Kinase Inhibitors
(therapeutic use)
- Pyrroles
(therapeutic use)
- Sunitinib
- Treatment Outcome
- Von Hippel-Lindau Tumor Suppressor Protein
(genetics)
- von Hippel-Lindau Disease
(complications, drug therapy, genetics)
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