Severe sepsis in a premature neonate: protein C replacement therapy.

Abstract

Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.

• Authors: Maria Pia De Carolis, Valentina Polimeni, Patrizia Papacci, Serafina Lacerenza, Costantino Romagnoli
• Journal: The Turkish journal of pediatrics (Turk J Pediatr) 2008 Jul-Aug Vol. 50 Issue 4 Pg. 405-8 ISSN: 0041-4301 [Print] Turkey
• PMID: 19014060 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• Protein C

Topics

• Anticoagulants (administration & dosage, therapeutic use)
• Drug Administration Schedule
• Humans
• Infant, Newborn
• Infant, Premature
• Male
• Protein C (administration & dosage, therapeutic use)
• Sepsis (drug therapy, physiopathology)