20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction.

Abstract

20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450 metabolite of arachidonic acid that regulates vascular function and sodium homeostasis. Studies showing an association between 20-HETE excretion, raised BMI, and oxidative stress suggest that 20-HETE may be important in the development of cardiovascular disease in the metabolic syndrome (MetS). We investigated whether 20-HETE and F(2)-isoprostanes (markers of oxidative stress) were altered in the MetS before and after weight reduction. A case-controlled comparison of 30 participants with the MetS and matched controls showed that plasma and urinary 20-HETE and F(2)-isoprostanes were significantly elevated in the MetS group. There was a significant gender x group interaction such that women with the MetS had higher urinary 20-HETE and F(2)-isoprostanes compared to controls (p<0.0001). In a randomized controlled trial, 42 participants with the MetS were assigned to 16 weeks of weight maintenance or a 12-week weight-loss program followed by 4 weeks weight stabilization. Relative to the weight-maintenance group, a 4-kg loss in weight resulted in a 2-mm Hg fall in blood pressure (BP) but did not alter urinary or plasma 20-HETE or F(2)-isoprostanes. 20-HETE and oxidative stress may be important mediators of cardiovascular disease risk in the MetS. Although a 4% reduction in body weight reduced BP, there were no changes in plasma or urinary 20-HETE or F(2)-isoprostanes.

• Authors: I-Jung Tsai, Kevin D Croft, Trevor A Mori, John R Falck, Lawrence J Beilin, Ian B Puddey, Anne E Barden
• Journal: Free radical biology & medicine (Free Radic Biol Med) Vol. 46 Issue 2 Pg. 263-70 (Jan 15 2009) ISSN: 1873-4596 [Electronic] United States
• PMID: 19013235 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• F2-Isoprostanes
• Hydroxyeicosatetraenoic Acids
• 20-hydroxy-5,8,11,14-eicosatetraenoic acid

Topics

• Adult
• Aged
• Biomarkers (blood, urine)
• Blood Pressure Monitoring, Ambulatory
• Cardiovascular Diseases (etiology)
• F2-Isoprostanes (blood, urine)
• Female
• Humans
• Hydroxyeicosatetraenoic Acids (blood, urine)
• Hypertension
• Male
• Metabolic Syndrome (blood, physiopathology, urine)
• Middle Aged
• Obesity
• Oxidative Stress (physiology)
• Risk Factors
• Weight Loss (physiology)