Abstract | INTRODUCTION: AIM: To evaluate the efficacy and safety of treatment with ezetimibe in kidney transplant recipients with uncontrolled hyperlipidemia. MATERIALS AND METHODS: We undertook a prospective study of 25 kidney transplant recipients with dyslipidemia who started treatment with 10 mg of ezetimibe. Statins were being taken by 96% of these patients. Monotherapy was used in one case. Measurements were made at baseline and after 3, 6, and 12 months of the lipid and hepatic profiles, CPK, lactose dehydrogenase, renal function and levels of immunosuppressive agents. RESULTS: CONCLUSIONS: The use of ezetimibe associated with statins is an efficient and safe therapeutic alternative for the treatment of poorly controlled dyslipidemia in recipients of a kidney graft.
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Authors | V López, C Gutiérrez, E Gutiérrez, E Sola, M Cabello, D Burgos, M González Molina |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 40
Issue 9
Pg. 2925-6
(Nov 2008)
ISSN: 0041-1345 [Print] United States |
PMID | 19010149
(Publication Type: Journal Article)
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Chemical References |
- Anticholesteremic Agents
- Azetidines
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Immunosuppressive Agents
- Lipids
- Triglycerides
- Cholesterol
- L-Lactate Dehydrogenase
- Creatine Kinase
- Ezetimibe
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Topics |
- Adult
- Aged
- Anticholesteremic Agents
(therapeutic use)
- Azetidines
(therapeutic use)
- Cardiovascular Diseases
(epidemiology)
- Cholesterol
(blood)
- Creatine Kinase
(blood)
- Drug Therapy, Combination
- Dyslipidemias
(drug therapy)
- Ezetimibe
- Female
- Follow-Up Studies
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Immunosuppressive Agents
(therapeutic use)
- Kidney Transplantation
(adverse effects, immunology)
- L-Lactate Dehydrogenase
(blood)
- Lipids
(blood)
- Male
- Middle Aged
- Prospective Studies
- Triglycerides
(blood)
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