Case report: severe microscopic polyangiitis successfully treated with extracorporeal membrane oxygenation and immunosuppression in a pediatric patient.

Abstract

Severe microscopic polyangiitis can result in acute respiratory failure and renal failure and is commonly treated with mechanical cardiopulmonary support, along with immunosuppression. We report the use of continuous renal replacement therapy and rituximab in a 13-year-old boy with P-antineutrophil cytoplasmic antibody-positive microscopic polyangiitis, resulting in pulmonary hemorrhage and acute renal failure. The patient was treated with high-frequency oscillatory ventilation, extracorporeal membrane oxygenation, and continuous renal replacement therapy, in addition to plasmapheresis, corticosteroids, cyclophosphamide, and rituximab.

• Authors: Michael V Di Maria, Roger Hollister, Jon Kaufman
• Journal: Current opinion in pediatrics (Curr Opin Pediatr) Vol. 20 Issue 6 Pg. 740-2 (Dec 2008) ISSN: 1531-698X [Electronic] United States
• PMID: 19005344 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Murine-Derived
• Immunologic Factors
• Immunosuppressive Agents
• Rituximab
• Cyclophosphamide

Topics

• Acute Kidney Injury (etiology, therapy)
• Adolescent
• Adrenal Cortex Hormones (administration & dosage)
• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Murine-Derived
• Cyclophosphamide (administration & dosage)
• Extracorporeal Membrane Oxygenation (methods)
• Hemorrhage (etiology, therapy)
• High-Frequency Ventilation (methods)
• Humans
• Immunologic Factors (administration & dosage)
• Immunosuppression Therapy (methods)
• Immunosuppressive Agents (administration & dosage)
• Lung Diseases (etiology, therapy)
• Male
• Plasmapheresis (methods)
• Renal Replacement Therapy (methods)
• Rituximab
• Severity of Illness Index
• Vasculitis (complications, immunology, therapy)