Abstract | OBJECTIVE: METHODS: A functional blocking monoclonal antibody for SHPS-1 (anti-SHPS-1 mAb) was administered at various doses to collagen-induced arthritis (CIA) mice, and severity of the arthritis was evaluated by clinical and histological scores of the limbs. To clarify the mechanisms of action of the antibody, the serum concentration of anti- type II collagen antibody was measured in those mice, and in vitro experiments were conducted to determine the effects of the antibody on the induction of osteoclasts and the release of cytokines from mouse spleen cells. RESULTS: CONCLUSION:
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Authors | Konagi Tanaka, Tatsuya Horikawa, Satsuki Suzuki, Kazutaka Kitaura, Junko Watanabe, Akito Gotoh, Noriyuki Shiobara, Tsunetoshi Itoh, Shoji Yamane, Ryuji Suzuki, Naoshi Fukui, Takahiro Ochi |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 35
Issue 12
Pg. 2316-24
(Dec 2008)
ISSN: 0315-162X [Print] Canada |
PMID | 19004048
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Ptpns1 protein, mouse
- Receptors, Immunologic
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Topics |
- Animals
- Antibodies, Monoclonal
(therapeutic use)
- Arthritis, Experimental
(drug therapy, immunology)
- Male
- Mice
- Receptors, Immunologic
(antagonists & inhibitors, immunology)
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