Abstract | BACKGROUND: METHODS: GBS cases (n = 133) were compared to age- and hospital-matched patient controls (n = 374). A nerve conduction study was performed on cases and a clinical history, serum sample, and stool specimen obtained for all subjects. RESULTS: Most (63.3%) cases were demyelinating type; median age four years. Cases were more likely than controls to have diarrhea (29.5% vs. 22.5%, Adjusted Odds Ratio (ORa) = 1.69, P = 0.03), to have higher geometric mean IgM anti-Campylobacter antibody titers (8.18 vs. 7.25 P<0.001), and to produce antiganglioside antibodies (e.g., anti-Gd1a, 35.3 vs. 11.5, ORa = 4.39, P<0.0001). Of 26 Penner:Lior Campylobacter serotypes isolated, only one (41:27, C. jejuni, P = 0.02) was associated with GBS. CONCLUSIONS: Unlike results from western nations, data suggested that GBS cases were primarily in the young and cases and many controls had a history of infection to a variety of Campylobacter serotypes. Still, the higher rates of diarrhea and greater antibody production against Campylobacter and gangliosides in GBS patients were consistent with findings from western countries.
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Authors | Thomas F Wierzba, Ibrahim Adib Abdel-Messih, Bayoumi Gharib, Shahida Baqar, Amina Hendaui, Ibrahim Khalil, Tarek A Omar, Hamed E Khayat, Shannon D Putnam, John W Sanders, Lai-King Ng, Lawrence J Price, Daniel A Scott, Robert R Frenck |
Journal | PloS one
(PLoS One)
Vol. 3
Issue 11
Pg. e3674
( 2008)
ISSN: 1932-6203 [Electronic] United States |
PMID | 19002255
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Campylobacter Infections
(complications, immunology)
- Child
- Child, Preschool
- Egypt
- Gangliosides
(immunology)
- Guillain-Barre Syndrome
(etiology, immunology, microbiology)
- Humans
- Infant
- Middle Aged
- Young Adult
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