Abstract | OBJECTIVE: DESIGN: Systematic review and meta-analysis of randomised controlled trials (RCTs). MEDLINE, EMBASE and the Cochrane Controlled Trials Register were searched (up to May 2008). SETTING: RCTs based in primary, secondary and tertiary care. PATIENTS: Adults with IBS. INTERVENTIONS: MAIN OUTCOME MEASURES: Dichotomous symptom data were pooled to obtain a relative risk (RR) of remaining symptomatic after therapy, with a 95% confidence interval (CI). The number needed to treat (NNT) was calculated from the reciprocal of the risk difference. RESULTS: CONCLUSIONS:
Antidepressants are effective in the treatment of IBS. There is less high-quality evidence for routine use of psychological therapies in IBS, but available data suggest these may be of comparable efficacy.
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Authors | A C Ford, N J Talley, P S Schoenfeld, E M M Quigley, P Moayyedi |
Journal | Gut
(Gut)
Vol. 58
Issue 3
Pg. 367-78
(Mar 2009)
ISSN: 1468-3288 [Electronic] England |
PMID | 19001059
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
- Antidepressive Agents
- Placebos
|
Topics |
- Adult
- Antidepressive Agents
(therapeutic use)
- Cognitive Behavioral Therapy
(methods)
- Combined Modality Therapy
(methods)
- Female
- Humans
- Irritable Bowel Syndrome
(drug therapy, psychology, therapy)
- Male
- Placebos
(therapeutic use)
- Practice Guidelines as Topic
- Randomized Controlled Trials as Topic
- Treatment Outcome
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