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Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.

AbstractETHNOPHARMACOLOGICAL RELEVANCE:
Tripterygium wilfordii Hook. f. (Celastraceae) has been traditionally used as folk medicine for centuries in China for the treatment of immune-inflammatory diseases.
AIM OF THE STUDY:
This study aimed to assess the antiangiogenic activities which support the therapeutic use of Tripterygium wilfordii and its terpenoids for angiogenesis disease such as cancer.
MATERIALS AND METHODS:
The ethanol extract of Tripterygium wilfordii and subsequent fractions were evaluated on an in vivo antiangiogenic zebrafish embryo model.
RESULTS:
Three antiangiogenic terpenoids were isolated by bioassay-guided purification, namely, celastrol (4), cangoronine (5) and triptolide (7). Among them, triptolide manifested the most potent antiangiogenic activity against vessel formation by nearly 50% at 1.2 microM. Semi-quantitative RT-PCR analysis revealed that triptolide dose- and time-dependently reduced the mRNA expression of angiopoietin (angpt)2 and tie2 in zebrafish, indicating the involvement of angpt2/tie2 signaling pathway in the antiangiogenic action of triptolide.
CONCLUSIONS:
The discovery of an alternative pathway further confirms the value of ethnopharmacological investigations into traditional botanicals for leads for potential drug development.
AuthorsMing-Fang He, Lin Liu, Wei Ge, Pang-Chui Shaw, Renwang Jiang, Li-Wha Wu, Paul Pui-Hay But
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 121 Issue 1 Pg. 61-8 (Jan 12 2009) ISSN: 0378-8741 [Print] Ireland
PMID18996177 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Angiogenesis Inhibitors
  • Diterpenes
  • Drugs, Chinese Herbal
  • Epoxy Compounds
  • Pentacyclic Triterpenes
  • Phenanthrenes
  • Terpenes
  • Triterpenes
  • cangoronine
  • triptolide
  • celastrol
Topics
  • Angiogenesis Inhibitors (chemistry, pharmacology)
  • Animals
  • Disease Models, Animal
  • Diterpenes (chemistry, pharmacology)
  • Drugs, Chinese Herbal (pharmacology)
  • Embryo, Nonmammalian (blood supply)
  • Epoxy Compounds (chemistry, pharmacology)
  • Neovascularization, Physiologic (drug effects)
  • Pentacyclic Triterpenes
  • Phenanthrenes (chemistry, pharmacology)
  • Plant Roots (chemistry)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Terpenes (chemistry, pharmacology)
  • Tripterygium (chemistry)
  • Triterpenes (chemistry, pharmacology)
  • Zebrafish

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