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[Effects of Xuefu Zhuyu Oral Liquid on hemorheology in patients with blood-stasis syndrome due to coronary disease and their relationship with human platelet antigen-3 polymorphism].

AbstractOBJECTIVE:
To investigate the effects of Xuefu Zhuyu Oral Liquid, a compound traditional Chinese herbal medicine for resolving stagnation, on hemorheology in the patients with blood-stasis syndrome due to coronary disease and their relationship with human platelet antigen-3 (HPA-3) polymorphism of membrane glycoprotein IIb (GPIIb).
METHODS:
Thirty-two patients with blood-stasis syndrome due to coronary disease were selected in this study. Blood-stasis syndrome scoring was performed and hemorheological parameters were measured in all subjects before and after Xuefu Zhuyu Qral Liquid treatment. The genotypes of GPIIb HPA-3 were determined by TaqMan probe technology.
RESULTS:
The hemorheology was improved in the patients with blood-stasis syndrome due to coronary heart disease after the treatment. There were significant differences in the whole blood viscosity, deformation index of red blood cells and scores of blood-stasis syndrome between the patients carrying AC plus CC and the patients carrying AA after the treatment (P<0.05).
CONCLUSION:
Xuefu Zhuyu Oral Liquid can improve clinical symptoms and hemorheology in the patients with blood-stasis syndrome due to coronary heart disease, which is related to GPIIb HPA-3 polymorphism.
AuthorsMei Xue, Ke-ji Chen, Xiao-juan Ma, Jian-gang Liu, Yue-rong Jiang, Yu Miao, Hui-jun Yin
JournalZhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao) Vol. 6 Issue 11 Pg. 1129-35 (Nov 2008) ISSN: 1672-1977 [Print] China
PMID18990338 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Human Platelet
  • Drugs, Chinese Herbal
  • Platelet Membrane Glycoprotein IIb
  • Xue-Fu-Zhu-Yu decoction
Topics
  • Aged
  • Antigens, Human Platelet (genetics)
  • Coronary Disease (blood, drug therapy, genetics)
  • Drugs, Chinese Herbal (therapeutic use)
  • Female
  • Genotype
  • Hemorheology (drug effects)
  • Humans
  • Male
  • Medicine, Chinese Traditional
  • Middle Aged
  • Platelet Membrane Glycoprotein IIb (genetics)
  • Polymorphism, Genetic

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