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Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia.

AuthorsW Deenik, H B Beverloo, S C P A M van der Poel-van de Luytgaarde, M M Wattel, J W J van Esser, P J M Valk, J J Cornelissen
JournalLeukemia (Leukemia) Vol. 23 Issue 3 Pg. 627-9 (Mar 2009) ISSN: 1476-5551 [Electronic] England
PMID18987655 (Publication Type: Case Reports, Letter)
Chemical References
  • NUP214-ABL1 fusion protein, human
  • Neoplasm Proteins
  • Oncogene Proteins, Fusion
  • Pyrimidines
  • Thiazoles
  • Cytarabine
  • Granulocyte Colony-Stimulating Factor
  • Vincristine
  • Mitoxantrone
  • Asparaginase
  • Dasatinib
  • Prednisone
  • Methotrexate
  • Daunorubicin
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Asparaginase (administration & dosage)
  • Combined Modality Therapy
  • Cytarabine (administration & dosage)
  • Dasatinib
  • Daunorubicin (administration & dosage)
  • Granulocyte Colony-Stimulating Factor (therapeutic use)
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Methotrexate (administration & dosage)
  • Mitoxantrone (administration & dosage)
  • Neoplasm Proteins (analysis, antagonists & inhibitors, genetics)
  • Neutropenia (chemically induced, drug therapy)
  • Oncogene Proteins, Fusion (analysis, antagonists & inhibitors, genetics)
  • Peripheral Blood Stem Cell Transplantation
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (complications, diagnosis, drug therapy, enzymology, genetics, surgery)
  • Prednisone (administration & dosage)
  • Pyrimidines (therapeutic use)
  • Remission Induction
  • Splenic Rupture (etiology, surgery)
  • Thiazoles (therapeutic use)
  • Vincristine (administration & dosage)
  • Young Adult

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