Fibrin glue administration to support bronchial stump line.

Bronchopleural fistula is an important cause of mortality and morbidity after pulmonary resection. The use of fibrin glue to reduce the tension and number of sutures in the bronchial stump was assessed in this prospective study of 20 patients between June 2002 and May 2003. They all had a high risk of bronchopleural fistula development because of bronchiectasis, tuberculosis, lung abscess, diabetes mellitus, preoperative neoadjuvant radiotherapy, or residual tumor at the surgical margin. After pulmonary resection, the bronchial stump was closed with separate nonabsorbable sutures supported with fibrin glue. Bronchopleural fistula was observed in only 1 (5%) patient during 6.45 +/- 3.09 months of follow-up. There was no postoperative mortality. Closing the bronchial stump with an appropriate technique and supporting it with fibrin glue were considered effective in preventing bronchopleural fistula development after pulmonary resection in high-risk patients.
AuthorsSoner Gursoy, Murat U Yapucu, Ahmet Ucvet, Serkan Yazgan, Oktay Basok, Sulun Ermete
JournalAsian cardiovascular & thoracic annals (Asian Cardiovasc Thorac Ann) Vol. 16 Issue 6 Pg. 450-3 (Dec 2008) ISSN: 1816-5370 [Electronic] England
PMID18984752 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Fibrin Tissue Adhesive
  • Tissue Adhesives
  • Adolescent
  • Adult
  • Aged
  • Bronchi (surgery)
  • Bronchial Fistula (etiology, prevention & control)
  • Female
  • Fibrin Tissue Adhesive (administration & dosage)
  • Humans
  • Male
  • Middle Aged
  • Pleural Diseases (etiology, prevention & control)
  • Pneumonectomy (adverse effects)
  • Prospective Studies
  • Respiratory Tract Fistula (etiology, prevention & control)
  • Risk Assessment
  • Risk Factors
  • Suture Techniques
  • Tissue Adhesives (administration & dosage)
  • Treatment Outcome
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!

Choose Username:
Verify Password:
Enter Code Shown: