Gadolinium-enhanced three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging is superior to spin-echo imaging in delineating brain metastases.

Abstract

BACKGROUND:

Precisely defining the number and location of brain metastases is very important for establishing a treatment strategy for malignancies. Although magnetic resonance imaging (MRI) is now considered the best modality, various improvements in sequences are still being made.

PURPOSE:

To prospectively compare the diagnostic ability of three-dimensional, magnetization-prepared rapid gradient-echo (3D MP-RAGE) imaging in detecting metastatic brain tumors, with that of two-dimensional spin-echo (2D SE) T1-weighted imaging.

MATERIAL AND METHODS:

A total of 123 examinations were included in this study, and 119 examinations from 88 patients with known malignancies were analyzed. All patients underwent T1- and T2-weighted 2D SE transverse imaging, followed by gadolinium-enhanced T1-weighted transverse and coronal 2D SE imaging and 3D MP-RAGE transverse imaging. Four radiologists interpreted the images to compare the accuracy and the time required for interpretation for each imaging.

RESULTS:

3D MP-RAGE imaging was significantly better than 2D SE imaging for detecting metastatic brain lesions, regardless of the readers' experience. The sensitivities of the 3D MP-RAGE and 2D SE imaging for all observers were 0.81 vs. 0.80 (P>0.05), specificities were 0.93 vs. 0.87 (P<0.05), positive predictive values were 0.92 vs. 0.86 (P<0.05), negative predictive values were 0.78 vs. 0.75 (P>0.05), and accuracies were 0.84 vs. 0.78 (P<0.05), respectively. There was no significant difference in the time required for image interpretation between the two modalities (15.6+/-4.0 vs. 15.4+/-4.1 min).

CONCLUSION:

3D MP-RAGE imaging proved superior to 2D SE imaging in the detection of brain metastases.

• Authors: T Takeda, A Takeda, T Nagaoka, E Kunieda, K Takemasa, M Watanabe, T Hatou, S Oguro, M Katayama
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 49 Issue 10 Pg. 1167-73 (Dec 2008) ISSN: 1600-0455 [Electronic] England
• PMID: 18979271 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Contrast Media
• Gadolinium DTPA

Topics

• Adult
• Aged
• Aged, 80 and over
• Brain Neoplasms (diagnosis, secondary)
• Contrast Media
• Female
• Gadolinium DTPA
• Humans
• Image Enhancement (methods)
• Imaging, Three-Dimensional (methods)
• Magnetic Resonance Imaging (methods)
• Magnetics
• Male
• Middle Aged
• Observer Variation
• Predictive Value of Tests
• Prospective Studies
• Reproducibility of Results
• Sensitivity and Specificity