Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: A regimen of 6-week/100 mg doxycycline per day sterilized adult female Onchocerca volvulus. Two hundred milligrams doxycycline per day for 4 or 6 weeks revealed 50 and 60% macrofilaricidal effects, respectively. Reduction of 80-90% of adult worms was observed in bancroftian filariasis with 200 mg/day doxycycline for 4 or 6 weeks. The latter regimen showed reduction of lymph vessel dilation and of hydrocele. Lymphoedema progression was halted and reversed in early stages. SUMMARY: Different options for antiwolbachial individual drug administration are summarized here. With improving health systems in endemic countries, individuals will demand best-possible treatment and accelerate a shift from mass drug administration-only approaches to integrated approaches combining both mass drug administration and individual drug administration. Treatment may be further improved by new antibiotics detected in high-throughput settings.
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Authors | Achim Hoerauf |
Journal | Current opinion in infectious diseases
(Curr Opin Infect Dis)
Vol. 21
Issue 6
Pg. 673-81
(Dec 2008)
ISSN: 1473-6527 [Electronic] United States |
PMID | 18978537
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Animals
- Doxycycline
(administration & dosage, therapeutic use)
- Elephantiasis, Filarial
(drug therapy)
- Filaricides
(administration & dosage, therapeutic use)
- Humans
- Onchocerca volvulus
(drug effects)
- Onchocerciasis
(drug therapy)
- Wuchereria bancrofti
(drug effects)
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