Abstract | OBJECTIVE: STUDY DESIGN: This was a retrospective chart review of 68 neonates and their mothers who received methadone therapy during pregnancy. The last dosage of maternal methadone just before delivery and the length of treatment for neonatal abstinence syndrome were examined with an analysis of variance model. RESULTS: When the data were analyzed for methadone dosages as a continuous variable, each 1-mg increase in the last maternal methadone dosage before delivery was associated with an additional 0.18 days of infant treatment for neonatal abstinence syndrome (P < .001; 95% CI, 0.112-0.255). In other words, every increase of 5.5 mg of methadone in the mother was associated statistically with 1 additional day of neonatal abstinence syndrome treatment for the infant. Gestational age at delivery and birthweight were not statistically significant. CONCLUSION:
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Authors | Susie Lim, Mona R Prasad, Philip Samuels, Debra K Gardner, Leandro Cordero |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 200
Issue 1
Pg. 70.e1-5
(Jan 2009)
ISSN: 1097-6868 [Electronic] United States |
PMID | 18976737
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Methadone
- Phenobarbital
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Topics |
- Adult
- Anticonvulsants
(therapeutic use)
- Cohort Studies
- Dose-Response Relationship, Drug
- Female
- Humans
- Infant, Newborn
- Methadone
(administration & dosage, adverse effects)
- Neonatal Abstinence Syndrome
(etiology)
- Phenobarbital
(therapeutic use)
- Pregnancy
- Pregnancy Outcome
- Regression Analysis
- Retrospective Studies
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