Abstract |
To study the efficacy of alpha lipoic acid (ALA) in a group of patients with burning mouth syndrome (BMS). Sixty BMS patients, 30 treated with ALA (Thioderm) 800 mg day(-1) for 8 weeks and 30 patients on the same protocol with a placebo. The symptomatology was measured on a Visual Analogue Scale (VAS). Sixty patients (54 females and 6 males, mean age 64.37 +/- 11.61 years) were included. Thirty-nine patients completed the treatment (23 with ALA and 16 with a placebo). Reviews were carried out at 0, 1 and 2 months. No statistically significant differences were found in the average pre- and post-treatment values for pain with the VAS scores, obtained in the placebo (6.6 +/- 2.5 - 2.8 +/- 25 = 3.8 +/- 3.7) versus ALA (6.3 +/- 2.8 - 4.0 +/- 2.7 = 2.2 +/- 2.6). Only one patient pertaining to the group treated with ALA abandoned because of adverse gastrointestinal side effects. The results showed no significant differences between the two groups.
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Authors | P López-Jornet, F Camacho-Alonso, S Leon-Espinosa |
Journal | Journal of oral rehabilitation
(J Oral Rehabil)
Vol. 36
Issue 1
Pg. 52-7
(Jan 2009)
ISSN: 1365-2842 [Electronic] England |
PMID | 18976257
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antioxidants
- Thioctic Acid
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Topics |
- Aged
- Antioxidants
(therapeutic use)
- Burning Mouth Syndrome
(drug therapy)
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Pain Threshold
(drug effects)
- Thioctic Acid
(therapeutic use)
- Treatment Outcome
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