Abstract | OBJECTIVE: In a previous study, urinary orosomucoid excretion rate (UOER) independently predicted cardiovascular mortality in patients with type 2 diabetes. The aim of the present study was to determine whether increased UOER is associated with cardiovascular risk factors such as inflammation, impaired left ventricular function and endothelial dysfunction in patients with type 2 diabetes. MATERIAL AND METHODS: RESULTS: Patients with diabetes and increased UOER had subclinically increased serum orosomucoid (p<0.001), C-reactive protein (CRP) (p<0.001), IL-6 (p<0.001), tPA (p<0.003) and sICAM (p<0.003) compared with healthy controls. In patients with type 2 diabetes, UOER was independently associated with increasing values of IL-6 (1.43 (1.06-1.93)) and tPA (1.82 (1.20-2.77)). Measurements by echocardiography showed no signs of cardiac dysfunction. CONCLUSIONS: Asymptomatic patients with type 2 diabetes and increased UOER displayed signs of chronic low-grade inflammation and endothelial dysfunction. UOER was independently related to markers of proinflammation and endothelial dysfunction in patients with type 2 diabetes. The previously shown relation between increased UOER and cardiovascular mortality is proposed to be caused by chronic low-grade inflammation and early endothelial dysfunction.
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Authors | M S Christiansen, K Iversen, C T Larsen, J P Goetze, E Hommel, J Mølvig, B K Pedersen, E Magid, B Feldt-Rasmussen |
Journal | Scandinavian journal of clinical and laboratory investigation
(Scand J Clin Lab Invest)
Vol. 69
Issue 2
Pg. 272-81
( 2009)
ISSN: 1502-7686 [Electronic] England |
PMID | 18972260
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-6
- Orosomucoid
- Intercellular Adhesion Molecule-1
- C-Reactive Protein
- Tissue Plasminogen Activator
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Topics |
- Adult
- Aged
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(blood, physiopathology, urine)
- Endothelium, Vascular
(physiopathology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Inflammation
(urine)
- Intercellular Adhesion Molecule-1
(blood)
- Interleukin-6
(blood)
- Male
- Middle Aged
- Orosomucoid
(urine)
- Tissue Plasminogen Activator
(blood)
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