A randomized trial of low-animal-protein or high-fiber diets for secondary prevention of calcium nephrolithiasis.

Abstract

BACKGROUND:

The purpose of this trial was to evaluate the efficacy of a low-animal-protein diet (LAPD) or a high-fiber diet (HFD) for the prevention of calcium nephrolithiasis recurrence.

METHODS:

We conducted a 4-year randomized trial comparing the effect of 2 diets in 175 idiopathic calcium stone formers. Fifty-five were assigned to a LAPD (<13% of total energy derived from protein), 60 were assigned to a HFD (>25 g/day fiber) and 60 were placed on a normal diet (control group). The primary outcome measure was the time to the first recurrence of calcium nephrolithiasis. Daily urine compositions were analyzed at baseline, at month 4 (M4), M12, M24, M36 and M48.

RESULTS:

Seventy-three patients completed the trial (23 in the LAPD group, 27 in the HFD group and 23 in the control group). Recurrence was 48% (11/23) in the LAPD group, 63% (17/27) in the HFD group and 48% (11/23) in the control group (p = not significant). During follow-up, urinary calcium levels and other urine parameters did not change significantly in the 3 groups, except for a significant decrease in 24-hour urinary sulfate in the LAPD group.

CONCLUSIONS:

In idiopathic calcium stone formers, neither a LAPD nor a HFD appeared to provide protection against recurrence.

• Authors: Bertrand Dussol, Cecilia Iovanna, Michel Rotily, Sophie Morange, Françoise Leonetti, Patricia Dupuy, Alain Vazi, Adriana Saveanu, Anderson Loundou, Yvon Berland
• Journal: Nephron. Clinical practice (Nephron Clin Pract) Vol. 110 Issue 3 Pg. c185-94 ( 2008) ISSN: 1660-2110 [Electronic] Switzerland
• PMID: 18957869 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright 2008 S. Karger AG, Basel.

Chemical References

• Dietary Fiber
• Dietary Proteins

Topics

• Adult
• Dietary Fiber (therapeutic use)
• Dietary Proteins (therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Nephrocalcinosis (diagnosis, diet therapy, prevention & control)
• Nephrolithiasis (diagnosis, diet therapy, prevention & control)
• Secondary Prevention
• Treatment Outcome