Parvalbumin-immunoreactive neurons in the cortex in Pick's disease.

Abstract

Parvalbumin (a calcium-binding protein)-immunoreactive (PV-Ir) neurons in the cerebral cortex were examined in 20 postmortem brains obtained from elderly controls and patients with Pick's disease (PD). The type of PV-Ir neurons and their distribution in control and PD brains were similar. The number of PV-Ir neurons in PD brains did not differ significantly from that in the control brains either. These findings suggested that PV-Ir neurons in the cortex are not affected in PD brains. A significant loss of PV-Ir neurons has already been reported in brains obtained from patients with Alzheimer-type dementia (ATD), and the present results suggest the possibility that the damage of PV-Ir neurons might be comparatively selective for ATD brains.

• Authors: H Arai, I Noguchi, Y Makino, K Kosaka, C W Heizmann, R Iizuka
• Journal: Journal of neurology (J Neurol) Vol. 238 Issue 4 Pg. 200-2 (Jul 1991) ISSN: 0340-5354 [Print] Germany
• PMID: 1895150 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Parvalbumins

Topics

• Aged
• Cerebral Cortex (chemistry)
• Dementia
• Frontal Lobe (chemistry)
• Humans
• Immunohistochemistry
• Middle Aged
• Neurons (chemistry)
• Parvalbumins (analysis)
• Reference Values
• Temporal Lobe (chemistry)