Abstract |
Parvalbumin (a calcium-binding protein)-immunoreactive (PV-Ir) neurons in the cerebral cortex were examined in 20 postmortem brains obtained from elderly controls and patients with Pick's disease (PD). The type of PV-Ir neurons and their distribution in control and PD brains were similar. The number of PV-Ir neurons in PD brains did not differ significantly from that in the control brains either. These findings suggested that PV-Ir neurons in the cortex are not affected in PD brains. A significant loss of PV-Ir neurons has already been reported in brains obtained from patients with Alzheimer-type dementia (ATD), and the present results suggest the possibility that the damage of PV-Ir neurons might be comparatively selective for ATD brains.
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Authors | H Arai, I Noguchi, Y Makino, K Kosaka, C W Heizmann, R Iizuka |
Journal | Journal of neurology
(J Neurol)
Vol. 238
Issue 4
Pg. 200-2
(Jul 1991)
ISSN: 0340-5354 [Print] Germany |
PMID | 1895150
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Cerebral Cortex
(chemistry)
- Dementia
- Frontal Lobe
(chemistry)
- Humans
- Immunohistochemistry
- Middle Aged
- Neurons
(chemistry)
- Parvalbumins
(analysis)
- Reference Values
- Temporal Lobe
(chemistry)
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