Abstract | BACKGROUND: METHODS: Sensitized animals were repeatedly challenged by pollen inhalation once every week. After the 7th challenge, the pollen extract was intranasally administered 6 times a week until the 30th challenge. Sneezing frequency was counted after each of the challenges. As an indicator of nasal blockage, changes in specific airway resistance were measured. Nasal hyperresponsiveness was assessed by measuring leukotriene D(4)-induced nasal blockage. Additionally, during the immunotherapy, we applied pollen onto the ocular surface to induce the allergic conjunctivitis symptoms. RESULTS: CONCLUSIONS: Local nasal immunotherapy may be clinically useful for allergic nasal blockage associated with nasal hyperresponsiveness. The mechanisms responsible for this effectiveness might not be related to IgE production. Additionally, the effectiveness for nasal tissue was dissociated from that seen for the ocular tissue.
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Authors | Takeshi Nabe, Kayoko Kubota, Nobuaki Mizutani, Masanori Fujii, Tetsuya Terada, Hiroshi Takenaka, Shigekatsu Kohno |
Journal | Allergology international : official journal of the Japanese Society of Allergology
(Allergol Int)
Vol. 57
Issue 4
Pg. 419-27
(Dec 2008)
ISSN: 1323-8930 [Print] England |
PMID | 18946238
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Allergens
- Antigens, Plant
- Cry j I protein, Cryptomeria japonica
- Cry j II protein, Cryptomeria japonica
- Epitopes
- Plant Proteins
- Immunoglobulin E
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Topics |
- Administration, Intranasal
- Allergens
(immunology)
- Animals
- Antibody Formation
- Antigens, Plant
(immunology)
- Conjunctivitis, Allergic
(complications, immunology, therapy)
- Cryptomeria
- Desensitization, Immunologic
- Disease Models, Animal
- Epitopes
- Guinea Pigs
- Immunization, Secondary
- Immunoglobulin E
(blood)
- Male
- Nasal Obstruction
(complications, immunology, therapy)
- Plant Proteins
(immunology)
- Pollen
(immunology)
- Rhinitis, Allergic, Seasonal
(complications, immunology, therapy)
- Sneezing
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