Abstract |
A 58-year-old man was admitted to hospital because of exertional dyspnoea and a cardiac murmur not previously heard. For one year he was known to have left-sided fibrinous pleuritis. For 5 years he had been taking methysergide for cluster headaches. From 1950-1980 he had worked with asbestos-containing insulating material. Erythrocyte sedimentation rate was greatly increased to 117/136 mm and there was an hypochromic anaemia (Hb 10.4 g/dl). The cholestasis enzymes were elevated (gamma-GT 88 U/l; alkaline phosphatase 511 U/l). Computed tomography of the thorax demonstrated left-sided pleural thickening of up to 3 cm. Endocarditis was excluded (sterile blood culture; normal echocardiogram). There was no evidence of an infectious, immunological or malignant cause for the pleural fibrosis. One year after pleurectomy and having discontinued methysergide all biochemical tests were normal.
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Authors | R Müller, P Weller, A Chemaissani |
Journal | Deutsche medizinische Wochenschrift (1946)
(Dtsch Med Wochenschr)
Vol. 116
Issue 38
Pg. 1433-6
(Sep 20 1991)
ISSN: 0012-0472 [Print] Germany |
Vernacular Title | Pleurafibrose als Nebenwirkung einer langjährigen Methysergid-Therapie. |
PMID | 1893855
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Biopsy
- Cluster Headache
(complications, drug therapy)
- Combined Modality Therapy
- Diagnosis, Differential
- Endocarditis, Subacute Bacterial
(diagnosis)
- Fibrosis
(chemically induced, diagnosis, therapy)
- Humans
- Lung
(pathology)
- Male
- Methysergide
(adverse effects)
- Middle Aged
- Pleura
(pathology, surgery)
- Pleurisy
(chemically induced, diagnosis, therapy)
- Propranolol
(therapeutic use)
- Time Factors
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