Expression of bone resorption regulators (RANK, RANKL, and OPG) in odontogenic tumors.

Abstract

OBJECTIVE:

To investigate the expression of bone resorption regulators (receptor activator of nuclear factor kappa B [RANK], RANK ligand [RANKL], and osteoprotegerin [OPG]) in calcifying cystic odontogenic tumor (CCOT), adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), odontogenic myxoma (OM), and ameloblastic fibroma (AF).

STUDY DESIGN:

The expression of these mediators was evaluated by means of immunohistochemistry.

RESULTS:

All specimens demonstrated positive immunoreactivity to RANK, RANKL, and OPG. The quantification of these mediators in epithelium revealed a similar pattern of expression for RANKL and OPG in CCOT, AOT, CEOT, and AF. With regard to stromal/mesenchymal cells, the majority of AOT and CCOT cases showed a higher content of OPG than RANKL, whereas CEOT, OM, and especially AF had a tendency to present a greater content of RANKL than OPG.

CONCLUSION:

Our data indicate that the CCOT, AOT, CEOT, OM, and AF cell constituents express key regulators of bone metabolism that might locally modulate tumor-associated bone resorption.

• Authors: Flávia R Andrade, Débora P Sousa, Elismauro F Mendonça, Tarcília A Silva, Vanessa S Lara, Aline C Batista
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 106 Issue 4 Pg. 548-55 (Oct 2008) ISSN: 1528-395X [Electronic] United States
• PMID: 18928898 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Osteoprotegerin
• RANK Ligand
• Receptor Activator of Nuclear Factor-kappa B

Topics

• Adult
• Alveolar Bone Loss (etiology, metabolism)
• Female
• Humans
• Immunohistochemistry
• Jaw Neoplasms (chemistry, complications, metabolism)
• Male
• Odontogenic Tumors (chemistry, complications, metabolism)
• Osteoclasts (metabolism)
• Osteolysis (etiology, metabolism)
• Osteoprotegerin (biosynthesis)
• RANK Ligand (biosynthesis)
• Receptor Activator of Nuclear Factor-kappa B (biosynthesis)
• Young Adult