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High beta-HPV DNA loads and strong seroreactivity are present in epidermodysplasia verruciformis.

Abstract
Epidermodysplasia verruciformis (EV) is a rare disease, characterized by cutaneous warts and associated with a strong predisposition to beta-genus human papillomavirus (HPV). Earlier studies reported high copy numbers of HPV-DNA in nearly all skin tumors from EV patients, but neither HPV replication status in non-lesional skin nor anti-HPV seroreactivity in these patients have been reported yet. We therefore performed a comprehensive viral load analysis for the more common beta-HPV types on skin samples and plucked eyebrow hairs from four EV patients treated at our dermatology department. The results clearly demonstrate that they carry a multiplicity (up to eighteen types) of beta-HPV genotypes in both skin sites. Worthy of note, a high intrapatient concordance for specific types between hair bulbs and skin biopsies was observed and the same beta-PV profile was maintained over time. Viral load analysis revealed a load range between less than one HPV-DNA copy per 100 cells to more than 400 HPV-DNA copies per cell in both eyebrow hairs and skin proliferative lesions. Evaluation of seroreactivity to beta-HPV types in the four EV patients revealed that antibodies against the 16 beta-HPV were significantly more prevalent and showed higher titers than in the controls.
AuthorsValentina Dell'Oste, Barbara Azzimonti, Marco De Andrea, Michele Mondini, Elisa Zavattaro, Giorgio Leigheb, Sönke J Weissenborn, Herbert Pfister, Kristina M Michael, Tim Waterboer, Michael Pawlita, Ada Amantea, Santo Landolfo, Marisa Gariglio
JournalThe Journal of investigative dermatology (J Invest Dermatol) Vol. 129 Issue 4 Pg. 1026-34 (Apr 2009) ISSN: 1523-1747 [Electronic] United States
PMID18923444 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Viral
  • DNA, Viral
Topics
  • Adult
  • Antibodies, Viral (blood)
  • Betapapillomavirus (classification, immunology, isolation & purification)
  • DNA, Viral (analysis)
  • Epidermodysplasia Verruciformis (immunology, virology)
  • Humans
  • In Situ Hybridization
  • Male
  • Middle Aged
  • Viral Load

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